1.
You cannot reason people out of a position that they did not reason themselves into.
Ben Goldacre
2.
Positive findings are around twice as likely to be published as negative findings. This is a cancer at the core of evidence-based medicine.
Ben Goldacre
3.
I'd like to submit to Bad Science my teacher who gave us a handout which says that 'Water is best absorbed by the body when provided in frequent small amounts.' What I want to know is this. If I drink too much in one go, will it leak out off my arsehole instead? Thank you. Anton.
Ben Goldacre
4.
The placebo effect is one of the most fascinating things in the whole of medicine. It's not just about taking a pill, and your performance and your pain getting better. It's about our beliefs and expectations. It's about the cultural meaning of a treatment.
Ben Goldacre
5.
You are a placebo responder. Your body plays tricks on your mind. You cannot be trusted.
Ben Goldacre
6.
Amazing things happen when you pull individual pieces of information together into larger linked datasets: meaning emerges, as you produce facts from figures.
Ben Goldacre
7.
If you put me in charge of the medical research budget, I would cancel all primary research, I would cancel all new trials, for just one year, and I would spend the money exclusively on making sure that we make the best possible use of the clinical evidence that we already have.
Ben Goldacre
8.
Science has authority not because of white coats or titles, but because of precision and transparency: you explain your theory, set out your evidence, and reference the studies that support your case.
Ben Goldacre
9.
And if, by the end [of this book], you reckon you might still disagree with me, then I offer you this: you'll still be wrong, but you'll be wrong with a lot more panache and flair than you could possibly manage right now.
Ben Goldacre
10.
There is this peculiar blind spot in the culture of academic medicine around whether withholding trial results is research misconduct. People who work in any industry can reinforce each others' ideas about what is okay.
Ben Goldacre
11.
Just just because there are flaws in aircraft design that doesn't mean flying carpets exist.
Ben Goldacre
12.
Teaching needs an ecosystem that supports evidence-based practice. It will need better systems to disseminate the results of research more widely, but also a better understanding of research, so that teachers can be critical consumers of evidence.
Ben Goldacre
13.
As it is a major component of blood, water is vital for transporting oxygen to the brain. Heaven forbid that your blood should dry out.
Ben Goldacre
14.
Transparency and detail are everything in science.
Ben Goldacre
15.
If I was writing a lifestyle book it would have the same advice on every page, and you’d know it all already. Eat lots of fruit and vegetables, and live your whole life in every way as well as you can: exercise regularly as part of your daily routine, avoid obesity, don’t drink too much, don’t smoke, and don’t get distracted from the real, basic, simple causes of ill health. But as we will see, even these things are hard to do on your own, and in reality require wholesale social and political changes.
Ben Goldacre
16.
The plural of anecdotes is not data
Ben Goldacre
17.
Most bloggers have no institutional credibility, and so they must build it, by linking transparently, and allowing you to easily double check their work. But more than anything, because linking sources is such an easy thing to do, and the motivations for avoiding links are so dubious, I've detected myself using a new rule of thumb: if you don't link to primary sources, I just don't trust you.
Ben Goldacre
18.
Real science is all about critically appraising the evidence for somebody else's position.
Ben Goldacre
19.
I spend a lot of time talking to people who disagree with me - I would go so far as to say that it's my favourite leisure activity.
Ben Goldacre
20.
In the past, [medicalization]has been portrayed as something that doctors inflict on a passive and un-suspecting world - an expansion of the Medical Empire. But in reality, it seems that these reductionist bio-medical stories can appeal to us all, because complex problems often have depressingly-complex causes, and the solutions can be taxing, and unsatisfactory.
Ben Goldacre
21.
Homeopathy pills are, after all, empty little sugar pills which seem to work, and so they embody [..] how we can be misled into thinking that any intervention is more effective than it really is.
Ben Goldacre
22.
There are many differences between medicine and teaching, but they have much in common. Both involve craft and personal expertise, learned through experience; but both can be informed by the experience of others.
Ben Goldacre
23.
Doctors and patients need as much data as possible to make an informed decision about what treatment is best.
Ben Goldacre
24.
I write about misuses of evidence in plenty of different spheres: scaremongering journalists, obvious quacks and naturopaths, and flaws in the way that evidence is used in mainstream academia, medicine and in (government) policy. One of the things I always found interesting is the same tricks are used to distort medicine in all of those domains.
Ben Goldacre
25.
I agree, the world would be a better place if doctors were less enthusiastic about adopting very new drugs.
Ben Goldacre
26.
I hope that you will be asked to participate in a trial at some stage in your disease
Ben Goldacre
27.
Data is the fabric of the modern world: just like we walk down pavements, so we trace routes through data, and build knowledge and products out of it.
Ben Goldacre
28.
Children can be disgusting, and often they can develop extraordinary talents, but I’m yet to meet any child who can stimulate his carotid arteries inside his ribcage.
Ben Goldacre
29.
I think you'll find it's a bit more complicated than that.
Ben Goldacre
30.
Yes. I'm a doctor, an epidemiologist, and lots of my professional colleagues flip back and forth between industry and medical roles. I know them; they are not bad people. But it is possible for good people in bad systems to do things that inflict enormous harm.
Ben Goldacre
31.
These corporations run our culture, and they riddle it with bullshit.
Ben Goldacre